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Scleromyxoedema often affects adults of 30-50 years of age. Men and women are equally affected.

Scleromyxoedema is characterised by widespread flesh-coloured papules affecting the the face, trunk and extremities. Mucous membranes and the scalp are not involved.

The papules (small bumps) are 2-3 mm in diameter, waxy and closely arranged in lines. They may become red-brown in colour.

As the condition progresses, deep furrows may develop across the brow. Skin stiffening of the skin, fingers (sclerodactyly) and reduced mobility of the mouth may occur resembling the scleroderma of systemic sclerosis but without telangiectasia or calcinosis.

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