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Toxic epidermal necrolysis (TEN) can be viewed as a severe form of erythema multiforme.

Typically a reaction to a drug, the skin becomes erythematous, with marked tenderness.

As the disease evolves, blisters and sheets of desquamation develop. The blisters rupture easily.

Mucous membranes are frequently involved.

There is an associated pyrexia and malaise.

Nikolsky sign is positive.

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