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Bullous Pemphigoid Bullous pemphigoid is a blistering skin disease, which usually affects middle aged or elderly persons.

Characteristically, crops of tense, fluid -filled blisters develop.

They may arise from normal-looking or reddened skin, often in body folds. Usually, the skin is very itchy.
Although sometimes pemphigoid is localized to one area such as an ankle, it is usually widespread.

The diagnosis is confirmed by taking a skin biopsy of a typical blister.

Under the microscope, the pathologist can see a split between the main layers of the skin, the epidermis and the dermis.

This occurs because antibodies and white blood cells attack the membrane that holds the skin together.

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