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Toxic shock syndrome (TSS) is an acute toxin-mediated illness caused by toxin-producing Staphy­lococcus aureus, characterized by rapid onset of fever, hypotension, generalized skin and mucosal erythema, and multisystem failure, occurring in menstrual (MTSS) and nonmenstrual (NMTSS) patterns. Rarely, group A streptococcus (GAS) produces streptococcal toxic shock-like syndrome (TSLS).


S. aureus multiplies in foreign body or minor wound infection, elaborating the TSST-1, which is absorbed and causes the clinical changes. TSST-1 causes decreased vasomotor tone and leakage of intravascular fluid. Rapid onset of hypotension followed by tissue ischemia and multisystem organ failure.


* A sudden high fever.
* Vomiting or diarrhea.
* A rash resembling a sunburn, particularly on your palms and soles. After a week or so, the skin on your hands and feet generally begins to peel.
* Confusion.
* Muscle aches.
* Redness of your eyes, mouth and throat.
* Seizures.
* Headaches.

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