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Graft-versus-host disease (GVHD) is an immune disorder caused by the reaction of histoincompatible, immunocompetent donor cells against the tissues of an immunoincompetent host (graft-versus-host reaction, GVHR), characterized by acute cutaneous changes ranging from maculopapular eruption to toxic epidermal necrolysis, diarrhea, and liver dysfunction, as well as chronic changes comprising lichenoid eruptions and sclerodermatous changes.

Acute GVHD


Causes:

GVHR associated with inflammatory reaction mounted by the donor cells against specific host organs-skin, liver, or GI tract. Severity of GVHD related to histocompatibility match between donor and recipient and preparatory regimen used. With successful engraftment, there is replacement of host marrow by immunocompetent donor cells capable of reacting against the "foreign" tissue antigens of the host.


Symptoms:

* Skin rash
* Abnormal liver function test
* Spots may coalesce to form widespread red rash
* Fever may be present

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